Human MCP1 ELISA kit (55R-1639)

ELISA kit for the detection of MCP1 in the research laboratory

Synonyms Human MCP1 ELISA kit, MCP1 ELISA kit, MCP1 ELISA kit, Monocyte Chemotactic antibody1 ELISA kit, CCL2 ELISA kit, MCAF ELISA kit, JE ELISA kit
Applications ELISA
Assay Information Sensitivity: 15.6 pg/ml-1000 pg/ml

Images

ELISA assay using Human MCP1 ELISA kit (55R-1639)

Graph showing ELISA absorbance curve (O.D.) of Human MCP1 (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant human MCP-1 standard: 10ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance Chemokines (chemoattractant cytokines) represent a superfamily of small secreted proteins that function as intercellular messengers to control migration and activation of leukocytes involved in inflammatory reactions and immunity. Furthermore, chemokines are important mediators of many pathologies such as allergic responses,chronic inflammatory and autoimmune diseases, tumor growth and hematopoietic development. The CC chemokine monocyte chemoattractant protein 1 (MCP1), also known as monocyte chemotactic and activating factor (MCAF) wascharacterized as a monocyte-specific chemoattractant that was later shown to attract also T lymphocytes and NK cells. The human mature MCP1 protein consists of 76 amino acids, derived by cleavage of a hydrophobic signal peptide from the 99 amino acid precursor protein. MCP1 is mainly expressed by macrophages in response to a wide range of cytokines such as IL6, TNF alpha and IL1 beta, but can, upon stimulation, also be produced by a variety of cells and tissues, such as fibroblasts, endothelial cells or certain tumor cells. Because of its target cell specificity, MCP1 was postulated to play a pathogenic role in a variety of diseases characterized by mononuclear cell infiltration, including atherosclerosis, rheumatoid arthritis and allergic responses. Elevated levels of MCP1 have also been found in connection with osseus inflammation and Alzheimer's disease (AD) as well as Myocardial Ischemia and viral infections.

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  • <div><font face=Calibri size=2>ELISA assay using Human MCP1 ELISA kit (55R-1639)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human MCP1 (pg/ml)

Availability: In stock

Price: $330.00
Size: 1 kit
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