Human MPO ELISA kit (55R-1772)

ELISA kit for the detection of MPO in the research laboratory

Synonyms Myeloperoxidase ELISA kit, MPO ELISA kit
Applications ELISA
Assay Information Sensitivity: 0.312ng/ml-20ng/ml

Images

ELISA assay using Human MPO ELISA kit (55R-1772)

Graph showing ELISA absorbance curve (O.D.) of Human MPO (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant human MPO standard: 20ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance Anti-neutrophilic cytoplasm antibodies (ANCA) represents a group of autoantibodies directed towards the cytoplasmatic components of the neutrophilic granulocytes and monocytes. The classical methods for the determination of ANCA are the immunofluorescent methods. With these indirect immunofluorescence techniques two main patterns are recognized, a cytoplasmatic (cANCA) and a perinuclear (pANCA) type. The main antigen for the cANCA is the proteinase 3 (PR3), which is a serine proteinase of the present in primary granules. Antibodies of pANCA positive sera are mainly directed to myeloperoxidase (MPO). Antibodies to other antigens e.g. lactoferrin, elastase, cathepsin G and also lysozyme often result in a similar pANCA pattern. Beside different untypical variants of pANCA IF patterns granulocyte specific antinuclear antibodies (GSANA) is indistinguishable from pANCA. This makes a clear interpretation and classification of the IF patterns difficult. Therefore every positive IFANCA finding esp. pANCA should be differenciated by ELISA techniques using purified antigens. PR3ANCA and MPOANCA are reliable serologic markers in the diagnostics of vasculitides. PR3ANCA is the classical autoantigen in Wegener

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  • <div><font face=Calibri size=2>ELISA assay using Human MPO ELISA kit (55R-1772)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human MPO (pg/ml)

Availability: In stock

Price: $440.00
Size: 1 kit
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