Human p53 ELISA kit (55R-1786)

ELISA kit for the detection of p53 in the research laboratory

Synonyms Human p53 ELISA kit
Applications ELISA
Assay Information Sensitivity: 156 pg/ml-10,000 pg/ml


ELISA assay using Human p53 ELISA kit (55R-1786)

Graph showing ELISA absorbance curve (O.D.) of Human P53 (pg/ml)


Form & Buffer This Kit contains: Lyophilized recombinant human P53 standard: 10ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance p53 is the most commonly mutated gene in human cancer. Mutations and allele loss in the gene located on chromosome 17p are the most frequent alterations yet identified in human malignancies. The p53 protein is highly conserved in evolution and expressed in most normal tissues. Wild-type p53 has been shown to be a sequence-specific transcription factor, directly interacting with various cellular and viral proteins. p53 is considered a stress response gene, the p53 protein acts to induce cell cycle arrest or apoptosis in response to DNA damage, thereby maintaining genetic stability in the organism. These functions are executed by a complex and incompletely understood series of steps known as the p53 pathway. Initially described as an oncogene, p53 was shown to be capable of suppressing the proliferation of transformed cells. Studies furthermore demonstrated that intact p53 function is essential for the maintenance of the nontumorgenic phenotype of cells. Thus p53 plays a vital role is suppressing the development of cancer. p53 is a tumor suppressor gene which induces apoptosis. An inverse relationship in some neoplasms has been shown between p53 and Bcl2, a protooncogene inhibiting apoptosis.

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  • <div><font face=Calibri size=2>ELISA assay using Human p53 ELISA kit (55R-1786)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human P53 (pg/ml)

Availability: In stock

Price: $460.00
Size: 1 kit
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