Human Survivin ELISA kit (55R-1723)

ELISA kit for the detection of Survivin in the research laboratory

Synonyms Human Survivin ELISA kit, BIRC5 ELISA kit, Baculoviral Inhibitor of Apoptosis Repeat-containing 5 ELISA kit
Applications ELISA
Assay Information Sensitivity: 62.5 pg/ml-4000 pg/ml

Images

ELISA assay using Human Survivin ELISA kit (55R-1723)

Graph showing ELISA absorbance curve (O.D.) of Human Survivin (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant human Survivin standard: 4ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or nondetectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase 3 and Caspase 7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivinepitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosisbased cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy.

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Images

  • <div><font face=Calibri size=2>ELISA assay using Human Survivin ELISA kit (55R-1723)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human Survivin (pg/ml)

Availability: In stock

Price: $475.00
Size: 1 kit
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