Human VEGFR1 ELISA kit (55R-1703)

ELISA kit for the detection of VEGFR1 in the research laboratory

Synonyms Human VEGFR1 ELISA kit, Vascular endothelial growth factor receptor ELISA kit, Flt1 ELISA kit
Applications ELISA
Assay Information Sensitivity: 156 pg/ml-10, 000 pg/ml

Images

ELISA assay using Human VEGFR1 ELISA kit (55R-1703)

Graph showing ELISA absorbance curve (O.D.) of Human sVEGFR1/sFLT1 (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant human VEGFR1 standard: 10ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance Soluble VEGFR1 (sFLT1) is a naturally occurring endogenous form of the VEGFR1 and was originally found in the supernatant of human vascular endothelial cells. It is generated by differential splicing of the flt 1 gene. In vitro sVEGFR1 is used to inhibit VEGFA mediated signals in endothelial cells and in vivo it can be used to block physiological angiogenesis in several organs, e.g. in the ovary or in bones. Tumor cells transfected with the flt1 gene are growth restricted in vivo because of the limitation in developing tumor blood vessels via VEGFA signalling. Very recent studies have shown that this molecule is present endogenously at ng/ml concentrations in biologicals fluids of normal human subjects or in the conditioned media of FLT1 positive cell types. The measurement of sFLT1 in a variety of clinical conditions may open up new insights in health and disease. Characterization of angiogenic activity, such as embryonic development, placental vascularization, cancer and wound healing is measured by comparing the ratio of angiogenic stimulators (e.g. FGF2, FGF1, VEGFA, Ang1) to angiogenic inhibitors (e.g. sFLT1, angiostatin, endostatin, thrombospondin).

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Images

  • <div><font face=Calibri size=2>ELISA assay using Human VEGFR1 ELISA kit (55R-1703)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human sVEGFR1/sFLT1 (pg/ml)

Availability: In stock

Price: $405.00
Size: 1 kit
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