IARS protein (His tag) (80-1377)

Purified recombinant IARS (OJ) protein (His tag)

Synonyms Isoleucyl-TRNA Synthetase protein, IleRS protein, OJ protein
Species Human
Protein Type Recombinant

Images

Coomassie blue stained SDS-PAGE of IARS protein (His tag) (80-1377)

Specifications

Residues 1-1262 aa
Expression System Baculovirus
Purity > 75% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 148 kDa
Tag/Conjugate His-GST tag
Form & Buffer Supplied in 50mM Tris buffer, pH 8.0, 150mM NaCl, 10% glycerol, 2mM MgCl2, 1mM EDTA and 2mM DTT

Storage & Safety

Storage Ships on dry ice. Upon receipt, aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance IARS belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis.
Expression IARS is expressed in response to inflammation and DNA damage. IARS is expressed in the membrane and cytoplasm of the majority of mammalian cells.
Implications in Disease Diseases associated with IARS include polymyositis, a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis, and dermatomyositis, a connective-tissue disease related to polymyositis (PM) that is characterized by inflammation of the muscles and the skin.
Post-Translational Modifications Ubiquitination occurs at Lys410, Lys450, Lys868, Lys917 and Lys1051.
Database Links Entrez Gene: 3376 Human, Omim: 600709 Human, SwissProt: P41252 Human

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Images

  • Coomassie blue stained SDS-PAGE of IARS protein (His tag) (80-1377)

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