ICAD protein (30R-3039)

Purified recombinant ICAD protein

Synonyms O00273 protein, ICAD protein, DFF 1 protein, DFF 45 protein, DFF alpha protein, DFF-45 protein, DFF45 protein
Species Human
Protein Type Recombinant
Applications WB

Images

Western Blot analysis using ICAD protein (30R-3039)

Specifications

Expression System E.coli
Purity > 95% pure
Molecular Weight 38 kDa
Form & Buffer Lyophilized from 50mM NaH2PO4, pH 8.0, 300mM NaCl, 130mM imidazole

Storage & Safety

Storage Store at -80 deg C. Avoid frequent freeze/thaw cycles

General Information

Biological Significance The inhibitor of caspase-3-activated DNase (ICAD) is a caspase 3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45 kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35 kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD.

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Images

  • Western Blot analysis using ICAD protein (30R-3039) |

Availability: In stock

Price: $295.00
Size: 200 ug
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