ICAM1 antibody (10R-1892)

Mouse monoclonal ICAM1 antibody

Synonyms Monoclonal ICAM1 antibody, Anti-ICAM1 antibody, Intercellular adhesion molecule 1 antibody, ICAM 1, ICAM1, CD54 antigen antibody, ICAM-1 antibody, ICAM-1 antibody, major group rhinovirus receptor antibody, ICAM 1 antibody, ICAM-1
Cross Reactivity Human
Applications ELISA, WB
Immunogen ICAM1 antibody was raised in Mouse using a purified recombinant fragment of human ICAM1(28-480aa) expressed in E. coli as the immunogen.

Images

Specifications

Host Mouse
Clone 6G12
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Product Use Monoclonal ICAM1 antibody specific for Human ICAM1 for use in ELISA and Western Blot.
Biological Significance ICAM1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. ICAM1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. ICAM1 is known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. More recently, ICAM1 has been characterized as a site for the cellular entry of human rhinovirus. Because of these associations with immune responses, it has been hypothesized that ICAM1 could function in signal transduction. ICAM1 also plays a major role in spermatogenesis due to its antagonistic effects on the tight junctions forming the blood-testis barrier.
Expression ICAM1 is typically expressed on endothelial cells and cells of the immune system. ICAM1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM1 is also located in the vascular endothelium, macrophages, and lymphocytes.
Implications in Disease ICAM1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds. ICAM1 has an important role in ocular allergies recruiting pro-inflammatory lymphocytes and mast cells promoting a type I hypersensitivity reaction.
Sequence Information ICAM1 is composed of 532 amino acids with a molecular weight of 57825 Da. It contains 5 Ig-like C2-type (immunoglobulin-like) domains at positions 41 – 103, 128 – 193, 230 – 297, 325 – 378 and 412 – 464. There is a cell attachment motif at positions 152 – 154.
Post-Translational Modifications ICAM1 is monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. Glycosylation occurs at Ile60, Asn130, Asn145, Asn183, Asn202, Asn267, Asn296, Asn385 and Asn406.
Database Links Entrez Gene: 3383 Human, Omim: 147840 Human, SwissProt: P05362 Human, Unigene: 643447 Human

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Images

  • Western Blot analysis using ICAM1 antibody (10R-1892) | Western Blot showing ICAM1 antibody used against ICAM1 (AA: 28-480)-hIgGFc transfected HEK293 (1) cell lysate.

Availability: In stock

Price: $325.00
Size: 100 ul
OR
Shipping
View Our Distributors