IFN beta 1 protein (His tag) (80R-1149)
Purified recombinant Mouse IFN beta 1 protein
|Synonyms||Interferon beta 1 protein, Ifb protein, IFN-beta protein, IFNB protein|
Coomassie Blue stained SDS-PAGE of IFN beta 1 protein (His tag) (80R-1149)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||22-182 amino acids: MGSSHHHHHH SSGLVPRGSH MINYKQLQLQ ERTNIRKCQE LLEQLNGKIN LTYRADFKIP MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI VVRLLDELHQ QTVFLKTVLE EKQEERLTWE MSSTALHLKS YYWRVQRYLK LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF QN|
|Purity||> 95% pure|
|Molecular Weight||22.0 kDa (182 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.1 M NaCl, and 30% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Interferon beta 1, also known as IFN-beta, is produced mainly by fibroblasts and some epithelial cell types. IFN-beta is involved in the regulation of non-specific humoral immune responses and immune responses against viral infections. It also increases the expression of HLA class I proteins and blocks the expression of HLA class II proteins stimulated by IFN-gamma. Interferon beta 1 can be used for topic treatment of condylomata acuminata. Some studies suggest that Interferon beta 1 tends to prevent disease activity in patients with multiple sclerosis. Recombinant Interferon beta 1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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