IGF1 protein (Mouse) (30R-AI148)

Purified recombinant Mouse IGF1 protein

Synonyms IGF-1 protein, IGF 1 protein, IGF1, IGF-1 protein, Somatamedin C protein, IGF-1, IGF-IA protein, Insulin-like Growth Factor-I protein, IGF 1
Species Mouse
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IGF1 protein corresponding to amino acids GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA.
Expression System E.coli
Purity > 98% pure
Molecular Weight 7.6 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 was determined a cell proliferation assay using FDC-P1 cells is 5 x 10^5 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

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Availability: In stock

Price: $225.00
Size: 50 ug
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