IGF1R antibody (10R-2108)
Mouse monoclonal IGF1R antibody
|Synonyms||Monoclonal IGF1R antibody, Anti-IGF1R antibody, Insulin-like growth factor 1 receptor antibody, IGFR 1 antibody, IGF1R, JTK13 antibody, CD221 antibody, CD221 antigen antibody, IGF-I receptor antibody, IGFR-1 antibody, IGFR 1, IGF I receptor antibody, IGFR-1|
|Applications||ELISA, IHC, WB|
|Immunogen||IGF1R antibody was raised in Mouse using a purified recombinant fragment of IGF1R expressed in E. coli as the immunogen.|
Immunohistochemical staining using IGF1R antibody (10R-2108)
Immunohistochemical analysis of paraffin-embedded human gastric adenocarcinoma(A), colon adenocarcinoma(B), endometrial carcinoma(uterus)(C), ovary adenocarcinoma(D), lung squamous cell carcinoma(E), stomach epithelium mucosae(F), showing membrane localization using IGF1R antibody with DAB staining.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||IGF1R binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-likegrowth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha andbeta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent byenhancing cell survival.|
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