IkB alpha antibody (10R-8517)

Mouse monoclonal IkB alpha antibody

Synonyms Monoclonal IkB alpha antibody, Anti-IkB alpha antibody, NFKBIA antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor antibody, alpha antibody, BOS_20329 antibody, ECI-6 antibody, ECI-6/IKBA antibody, ikappaBalpha antibody, I kappa B-alpha antibody, I-kappaBalpha antibody, I-kappa-B-alpha antibody, IkappaB alpha antibody, I(Kappa)B(alpha) antibody, IKBA antibody, ikB-alpha antibody, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha antibody, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells antibody, alpha antibody, MAD-3 antibody, major histocompatibility complex enhancer-binding protein MAD3 antibody, NF-kappa-B inhibitor alpha antibody, NF-kappaB inhibitor alpha antibody, Nfkbi antibody, nuclear factor of kappa light chain gene enhancer in B-cells antibody, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor antibody, alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor antibody, alpha antibody, nuclear factor of kappa light polyp gene enhancer in B-cell 1 antibody, Rel-associated pp40 antibody, REL-associated protein pp40 antibody, RL/IF-1 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen IkB alpha antibody was raised in Mouse using a recombinant human protein purified from E.coli(His/ABD-IkBa) as the immunogen

Images

Western Blot analysis using IkB alpha antibody (10R-8517)

Specifications

Host Mouse
Clone 7A4
Isotype IgG1 kappa
Method of Purification IkB alpha antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance IKB alpha is the major IKB protein member of IKB family that function to inhibit the NF-KB transcription factor. IKBs have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus. IKBalpha inhibits NF-KB by masking the nuclear localization signals (NLS) of NF-KB proteins and keeping them in an inactive state in the cytoplasm. In addition, IKBalpha blocks the ability of NF-KB transcription factors to bind to DNA, which is required for NF-KB's proper functioning.

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Images

  • Western Blot analysis using IkB alpha antibody (10R-8517) |

Availability: In stock

Price: $295.00
Size: 100 ul
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