IKBKB antibody (10R-2089)

Mouse monoclonal IKBKB antibody

Synonyms Monoclonal IKBKB antibody, Anti-IKBKB antibody, Inhibitor of kappa light polypeptide gene enhancer in B-cells antibody, IKKB antibody, IKK2 antibody, IKKB antibody, Kinase beta antibody, Inhibitor of kappa light polypeptide gene enhancer in B-cells antibody, Anti IKBKB antibody, IKBKB antibody, Kinase beta antibody, IKK2 antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen IKBKB antibody was raised in Mouse using a purified recombinant fragment of IKBKB expressed in E. coli as the immunogen.

Images

Western Blot analysis using IKBKB antibody (10R-2089)

Western Blot showing IKBKB antibody used against truncated IKBKB recombinant protein (1) and K562 cell lysate (2).

Specifications

Host Mouse
Clone 10A2
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance IKBKB is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

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Images

  • Western Blot analysis using IKBKB antibody (10R-2089) | Western Blot showing IKBKB antibody used against truncated IKBKB recombinant protein (1) and K562 cell lysate (2).

Availability: In stock

Price: $375.00
Size: 100 ul
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