IKBKB antibody (10R-2089)
Mouse monoclonal IKBKB antibody
|Synonyms||Monoclonal IKBKB antibody, Anti-IKBKB antibody, Inhibitor of kappa light polypeptide gene enhancer in B-cells antibody, IKKB antibody, IKK2 antibody, IKKB antibody, Kinase beta antibody, Inhibitor of kappa light polypeptide gene enhancer in B-cells antibody, Anti IKBKB antibody, IKBKB antibody, Kinase beta antibody, IKK2 antibody|
|Immunogen||IKBKB antibody was raised in Mouse using a purified recombinant fragment of IKBKB expressed in E. coli as the immunogen.|
Western Blot analysis using IKBKB antibody (10R-2089)
Western Blot showing IKBKB antibody used against truncated IKBKB recombinant protein (1) and K562 cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||IKBKB is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.|
Sorry, but there are no references currently for this product.
Sorry there are currently no reviews for this product