IL1 alpha protein (30R-AI017)

Purified recombinant Human IL1 alpha protein

Synonyms Interleukin 1 alpha protein, Leukocyte Endogenous Mediator protein, MCF protein, EP protein, LAF protein, Hematopoietin-1 protein, Lymphocyte-activating factor protein, IL-1, IL1, IL-1 alpha protein, Mononuclear Cell Factor protein, Endogenous Pyrogen protein, IL 1 protein, LEM protein, IL 1, IL-1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL1 alpha protein corresponding to amino acids SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA.
Expression System E.coli
Purity > 98% pure
Molecular Weight 18 kDa
Form & Buffer Lyophilized from 10mM tris, pH 8.0, with 50mM NaCl. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent stimulation of Mouse D10S cells is approximately 0.001 ng/ml, corresponding to a specific activity of approximately 1 x 10^9 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine.

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Availability: In stock

Price: $225.00
Size: 10 ug
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