IL1 beta protein (His tag) (80R-1044)
Purified recombinant Mouse IL1 beta protein
|Synonyms||IFN beta inducing factor protein, Interleukin 1 beta Catabolin protein, IL-1 beta protein, Mouse IL1 beta protein, IL 1B protein, Preinterleukin beta protein, Interleukin 1 beta precursor protein, LAF protein, IL1F2 protein, IL1B protein, IL beta-1, H1 protein, IL 1 beta protein, IL-1b protein, Hematopoietin 1 protein, IL-1beta protein, OAF protein, IL1 beta, IL beta 1, Osteoclast activating factor protein, Pro interleukin 1 beta, IL beta 1 protein, IL beta-1 protein, IL 1 protein, Interleukin 1 beta protein|
Coomassie Blue stained SDS-PAGE of IL1 beta protein (His tag) (80R-1044)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||118-269 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMVPI RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS TSQAEHKPVF LGNNSGQDII DFTMESVSS|
|Purity||> 90% pure|
|Molecular Weight||21 kDa (189aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||IL-1 beta is an inflammatory cytokine that might modulate angiogenesis by directly interacting with vascular endothelial cells or enhancing the production of proangiogenic factors via paracrine control. IL-1 beta stimulates endothelial cell migration and proliferation, adhesion-molecule expression, inflammatory mediator production, and leukocyte recruitment. IL-1 beta is required for tumor growth, metastasis, and angiogenesis in several animal models. Recombinant mouse IL-1 beta, fused to His tag, was expressed in E. coli and purified by using conventional chromatography techniques.|
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