IL16 protein (30R-AI013)

Purified recombinant Human IL16 protein

Synonyms Interleukin 16 protein, IL 16 protein, IL-16, IL16, LCF protein, IL-16 protein, IL-16 protein, Lymphocyte Chemoattractant Factor protein, IL 16
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL16 protein corresponding to amino acids MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS.
Expression System E.coli
Purity > 98% pure
Molecular Weight 13.5 kDa
Form & Buffer Lyophilized from 5mM Na3PO4, pH 7.6. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to chemoattract human CD4+ T lymphoytes using a concentration range of 1.0-100.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL16 exists predominantly as a noncovalently linked multimer, but that some IL16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL16 also induces expression of IL2 receptor (IL2R) and MHC class II molecules on CD4 + T cells. Human and Mouse IL16 show significant cross-species reactivity.

References
Add a Paper

Changbao Liu, Juliane Mills, Ken Dixon, Joseph Vennarini, Mark Cunningham, Alfred Del Vecchio, Anuk Das, William Glass

IL-16 signaling specifically induces STAT6 activation through CD4

Cytokine

Volume: 38 Issue: 3 Page: 145-150 DOI: 10.1016/j.cyto.2007.05.016

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Availability: In stock

Price: $225.00
Size: 10 ug
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