IL17 protein (30R-AI014)

Purified recombinant Human IL17 protein

Synonyms IL-17, Interleukin 17 protein, IL-17 protein, IL17, IL 17, CTLA-8 protein, IL-17 protein, IL 17 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL17 protein corresponding to amino acids MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA.
Expression System E.coli
Purity > 98% pure
Molecular Weight 31 kDa
Form & Buffer Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml. Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance The originally described IL17 protein, now known as IL17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL17A through IL17F, are secreted as homodimers. IL17A exhibits cross-species bioactivity between human and Mouse cells.

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Availability: In stock

Price: $225.00
Size: 25 ug
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