IL18BP protein (His tag) (80R-2644)
Purified recombinant Human IL18BP protein (His tag)
|Synonyms||ILBP 18, ILBP-18 protein, IL18BP, IL 18BPa protein, ILBP 18 protein, Interleukin-18-binding protein protein, IL-18BPa protein, ILBP-18, Interleukin 18 binding protein protein, IL18BPa protein|
SDS-PAGE analysis of IL18BP protein (His tag) (80R-2644)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||31-194 aa: MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG|
|Method of Purification||IL18BP protein was purified using Protein G affinity chromatography|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.|
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