IL1a antibody (10R-1883)
Mouse monoclonal IL1a antibody
|Synonyms||Monoclonal IL1a antibody, Anti-IL1a antibody, IL1a, IL 1a antibody, IL 1a, IL-1 alpha antibody, IL-1a, IL-1a antibody, IL-1a antibody, Interleukin 1 alpha antibody|
|Immunogen||IL1a antibody was raised in Mouse using a purified recombinant fragment of human IL1a expressed in E. coli as the immunogen.|
Western Blot analysis using IL1a antibody (10R-1883)
Western Blot showing IL1a antibody used against truncated IL1a recombinant protein.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL2 release, B-cell maturation and proliferation, mitogenic FGFlike activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL1beta is a secreted cytokine, IL1a is predominantly a cell-associated cytokine.|
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