IL21 protein (30R-AI116)

Purified recombinant Human IL21 protein

Synonyms Za11 protein, Interleukin 21 protein, IL 21, IL-21, IL 21 protein, IL-21 protein, IL-21 protein, IL-21 protein, IL21
Species Human
Protein Type Recombinant
Applications User optimized
Assay Information Protein quantitation was carried out by two independent methods. 1. UV spectroscopy at 280 nm using the absorbency value of 0.54 as the extinction coefficient for a 0.1% (1mg/ml) solution. 2. Analysis by RP-HPLC, using a standard solution of IL-21 as a Reference Standard.

Specifications

Expression System E.coli
Purity > 95% pure
Molecular Weight 15,463 Da
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity ED50 = 1.0-10 ng/ml, determined by the dose-dependant proliferation of human peripheral blood mononuclear cells.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

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Availability: In stock

Price: $195.00
Size: 10 ug
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