IL33 antibody (10R-1085)

Mouse monoclonal IL33 antibody

Synonyms Monoclonal IL33 antibody, Anti-IL33 antibody, IL-33, Interleukin 33 precursor antibody, IL 33 antibody, IL-33 antibody, NKHEV antibody, NF HEV antibody, IL 33 antibody, NF-HEV antibody, INTERLEUKIN 33 NFHEV antibody, Nuclear factor from high endothelial venules antibody, IL1F11 antibody, DVS27 antibody, RP11 575C20.2 antibody, Interleukin33 antibody, Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26 antibody, Interleukin 1 family member 11 antibody, IL33, DVS27 related protein antibody, IL-33 antibody, IL 33, IL 1F11 antibody, Interleukin 33 antibody, DKFZp586H0523 antibody, C9orf26 antibody, il33 antibody, NFHEV antibody
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen IL33 antibody was raised in mouse using recombinant human IL-33 (112-270aa) purified from E. coli as the immunogen.

Specifications

Host Mouse
Clone 4E9
Isotype IgG2b kappa
Source Anti-human IL-33 antibody, clone 4E9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-33 protein.
Method of Purification IL33 antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:1,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

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Availability: In stock

Price: $265.00
Size: 100 ul
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