IL33 protein (30R-AI118)

Purified recombinant Human IL33 protein

Synonyms IL 33 protein, IL-33, IL-33 protein, Interleukin 33 protein, IL-33 protein, NF-HEV protein, IL 33, IL33
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL33 protein corresponding to amino acids MSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET.
Expression System E.coli
Purity > 98% pure
Molecular Weight 15.8 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse D10S cells is approximately 0.05 ng/ml, corresponding to a specific activity of approximately 2 x 10^7units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Human IL31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.

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Availability: In stock

Price: $225.00
Size: 10 ug
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