INSR antibody (70R-10509)

Affinity purified rabbit polyclonal INSR antibody

Synonyms Polyclonal INSR antibody, Anti-INSR antibody, Insulin receptor antibody, CD220 antibody, HHF5 antibody
Cross Reactivity Human, Mouse, Rat, Dog, Rabbit, Zebrafish, African Clawed Frog
Applications IHC, WB
Immunogen INSR antibody was raised in rabbit using the middle region of INSR as the immunogen
Assay Information INSR Blocking Peptide, catalog no. 33R-8809, is also available for use as a blocking control in assays to test for specificity of this INSR antibody

Images

Immunohistochemical staining using INSR antibody (70R-10509)

INSR antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1.

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Images

  • Immunohistochemical staining using INSR antibody (70R-10509) | INSR antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X
  • Western Blot analysis using INSR antibody (70R-10509) | INSR antibody (70R-10509) used at 2.5 ug/ml to detect target protein.

Availability: In stock

Price: $345.00
Size: 50 ug
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