Inter alpha Trypsin Inhibitor antibody (10R-8431)

Mouse monoclonal Inter alpha Trypsin Inhibitor antibody

Synonyms Monoclonal Inter alpha Trypsin Inhibitor antibody, Anti-Inter alpha Trypsin Inhibitor antibody, ITIH1 antibody, inter-alpha-trypsin inhibitor heavy chain 1 antibody, BOS_20950 antibody, H1P antibody, IATIH antibody, IGHEP1 antibody, inter-alpha (globulin) inhibitor H1 antibody, inter-alpha (globulin) inhibitor antibody, H1 polypeptide antibody, inter-alpha-inhibitor heavy chain 1 antibody, inter-alpha-trypsin inhibitor complex component III antibody, inter-alpha trypsin inhibitor antibody, heavy chain 1 antibody, inter-alpha-trypsin inhibitor heavy chain H1 antibody, inter-alpha-trypsin inhibitor heavy-chain H1 antibody, Intin1 antibody, ITIH antibody, Itih-1 antibody, ITI HC1 antibody, ITI-HC1 antibody, ITI heavy chain H1 antibody, serum-derived hyaluronan-associated protein antibody, SHAP antibody
Cross Reactivity Human
Applications IHC-P, WB
Immunogen Inter alpha Trypsin Inhibitor antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Inter alpha Trypsin Inhibitor antibody (10R-8431)

Specifications

Host Mouse
Clone 40B10
Isotype IgG1 kappa
Method of Purification Inter alpha Trypsin Inhibitor antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:500-1000, IHC-P

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The inter-alpha-trypsin inhibitor (ITI, IalphaI) family, a typical and classical example for protein-glycosaminoglycan-protein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.

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Images

  • Western Blot analysis using Inter alpha Trypsin Inhibitor antibody (10R-8431) |

Availability: In stock

Price: $295.00
Size: 100 ul
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