IPPPOZ domain protein (30R-1039)
Purified recombinant Human IPPPOZ domain protein
|Synonyms||Protein phosphatase 1 regulatory subunit 1A, Actin binding protein IPP protein, Protein phosphatase inhibitor 1 protein, MIPP protein protein, Intracisternal A particle promoted polypeptide protein, Kelch like protein 27 protein, IPP-POZ domain protein, KLHL27 protein, I1 protein, IPP POZ protein, Actin-binding protein IPP protein, IPP protein, Intracisternal A particle-promoted polypeptide isoform 1 protein, Kelch-like protein 27 protein|
Coomassie Blue stained SDS-PAGE of IPPPOZ domain protein (30R-1039)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-157 amino acids: MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEF|
|Purity||> 95% pure|
|Molecular Weight||17.3 kDa (157 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 10mM HEPES, pH7.4, 25mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Intracisternal A particle-promoted polypeptide(IPP) is a 66kDa protein (584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-termina kelch repeat domain consisting of six tandem arranged repeats. The POZ domain (also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in proteins that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. IPP-POZ domain (1-157aa) was overexpressed in E. coli and purified by using conventional chromatography techniques.|
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