IRS2 antibody (10R-8572)

Mouse monoclonal IRS2 antibody

Synonyms Monoclonal IRS2 antibody, Anti-IRS2 antibody, IRS2 antibody, insulin receptor substrate 2 antibody, 4PS antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2-B antibody, irs1 antibody, IRS-1 antibody, Irs-2 antibody, irs2-b antibody, IRS-2-B antibody, tyrosine kinase substrate antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen IRS2 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-IRS2) as the immunogen

Images

Western Blot analysis using IRS2 antibody (10R-8572)

Specifications

Host Mouse
Clone AF2F2
Isotype IgG1 kappa
Method of Purification IRS2 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism through insulin/insulin like growth factor (IGF) signaling. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. After phosphorylation by activated receptors, these intracellular signaling molecules recruit various downstream effector pathways including phosphatidylinositol 3-kinase, tyrosine protein phosphatase SHPTP-2, and several smaller adapter molecules such as the growth factor receptor-binding protein Grb-2.

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Images

  • Western Blot analysis using IRS2 antibody (10R-8572) |

Availability: In stock

Price: $295.00
Size: 100 ul
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