ITGA5 antibody (10R-1984)

Mouse monoclonal ITGA5 antibody

Synonyms Monoclonal ITGA5 antibody, Anti-ITGA5 antibody, ITGA-5 antibody, ITGA 5 antibody, Integrin alpha 5 chain antibody, Integrin alpha chain 5 antibody, Integrin alpha 5 antibody, ITGA5, ITGA 5, ITGA-5, ITGA 5 antibody, ITGA-5 antibody
Cross Reactivity Human
Applications ELISA, FC, WB
Immunogen ITGA5 antibody was raised in Mouse using a purified recombinant fragment of human ITGA5 expressed in E. coli as the immunogen.

Images

Flow Cytometric assay using Western Blot analysis using ITGA5 antibody (10R-1984) (ITGA5 antibody)

FC analysis of Hela cells using ITGA5 antibody (green) and negative control (purple).

Specifications

Host Mouse
Clone 10F6
Isotype IgG2a
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, FC: 1:200-1:400, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance ITGA5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGA5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.

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Images

  • Flow Cytometric assay using Western Blot analysis using ITGA5 antibody (10R-1984) (ITGA5 antibody) | FC analysis of Hela cells using ITGA5 antibody (green) and negative control (purple).
  • Western Blot analysis using ITGA5 antibody (10R-1984) | Western Blot showing ITGA5 antibody used against ITGA5-hIgGFc transfected HEK293 cell lysate.
  • Immunohistochemical staining using ITGA5 antibody (10R-1984) | Immunohistochemical analysis of paraffin-embedded human Placenta tissues using ITGA5 antibody

Availability: In stock

Price: $345.00
Size: 100 ul
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