Keratin K18 antibody (10R-2389)

Mouse monoclonal Keratin K18 antibody

Synonyms Monoclonal Keratin K18 antibody, Anti Keratin K18 antibody, Keratin K 18 antibody, Keratin K18, Keratin K-18 antibody, Keratin K-18, Keratin K 18, Cytokeratin 18 antibody
Cross Reactivity Mouse, Rat, Bovine, Pig, Dog, Hamster, Sheep, Fish
Applications IHC, WB
Immunogen Keratin K18 antibody was raised in mouse using human keratin K18 from HeLa cytoskeletal preparation as the immunogen.

Specifications

Host Mouse
Clone Ks18.04
Isotype IgG1
Method of Purification Keratin K18 antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form, contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at 2-8 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

References
Add a Paper

Shuang Cuia, Louis M. Capeccia, Randolph P. Matthews

Disruption of planar cell polarity activity leads to developmental biliary defects

Developmental Biology

Volume: 351 Issue: 2 Page: 229-241 DOI: 10.1016/j.ydbio.2010.12.041

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