KIR3DL1 protein (His tag) (80R-1853)
Purified recombinant Human KIR3DL1 protein
|Synonyms||MGC119726 protein, NK-associated transcript 10 protein, short cytoplasmic tail protein, MHC class I NK cell receptor protein, CD158E2 protein, Killer cell immunoglobulin-like receptor 3DL1 AMB11 protein, Kirl2 protein, KIR protein, CD1 protein, NKAT-3 protein, KIR G1 protein, NK-associated transcript 3 protein, CL11 protein, Natural killer associated transcript 3 protein, KIR3, NKB1B protein, CD158E1 protein, CD158e protein protein, KIR 3 protein, KIR 3, CD158E1/2 protein, p70 killer cell inhibitory receptor protein, Natural killer cell inhibitory receptor protein, NK receptor protein, Killer cell immunoglobulin-like receptor 3DL1 protein, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1 protein, HLA-BW4-specific inhibitory NK cell receptor protein, KIR3DL1 protein, killer cell immunoglobulin like receptor protein, NKAT3 protein, Killer cell immunoglobulin like receptor three domains protein, KIR3DL1 (Cytoplasmic tail protein, NKAT10 protein, Natural killer-associated transcript 3 protein, Kirl1 protein, p70 natural killer cell receptor clones CL-2/CL-11 protein, KIR3DS1 protein, MGC119728 protein, NK-associated transcript 3delIg1 protein, CD158 protein-like family member E protein, 1 protein, MGC126591 protein, NKB1 protein, HLA-BW4-specific inhibitory NK cell receptor protein, , KIR-3 protein, KIR-3, KIR protein 3DL1 protein, CD158E protein, MGC126589 protein, CL2 protein, Krl1 protein, 361-444aa) protein|
Coomassie Blue stained SDS-PAGE of KIR3DL1 protein (His tag) (80R-1853)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||Cytoplasmic tail 361-444 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHL WCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP|
|Purity||> 95% pure|
|Molecular Weight||15 kDa (132 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 25mM Tris-HCl, pH7.5, containing 100mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The three Ig-domain from of inhibitory killer cell Ig-like receptor 1 (KIR3DL1,NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DLl recognizes the Bw4 determinant defined by sequence motifs at positions 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail (361-444aa) was overexpressed as insoluble protein aggregates (inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.|
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