KLHL12 antibody (10R-1948)
Mouse monoclonal KLHL12 antibody
|Synonyms||Monoclonal KLHL12 antibody, Anti-KLHL12 antibody, KLHL 12, KLHL12, KLHL 12 antibody, KLHL-12, KLHL-12 antibody, KLHL-12 antibody, KLHL 12 antibody|
|Immunogen||KLHL12 antibody was raised in Mouse using a purified recombinant fragment of human KLHL12 expressed in E. coli as the immunogen.|
Western Blot analysis using KLHL12 antibody (10R-1948)
Western Blot showing KLHL12 antibody used against Hela (1) cell lysate.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||KLHL12 serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. It negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3. It is highly expressed in testis and at lower levels in the submandibular salivary gland.|
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