KSHV ORF45 antibody (10R-1940)

Mouse monoclonal KSHV ORF45 antibody

Synonyms Monoclonal KSHV ORF45 antibody, Anti-KSHV ORF45 antibody, KSHV ORF-45, KSHV ORF 45, KSHV ORF 45 antibody, Open Reading Frame 45 antibody, KSHV ORF-45 antibody, Kaposis sarcoma-associated herpesvirus antibody, KSHV ORF45
Applications ELISA, ICC, WB
Immunogen KSHV ORF45 antibody was raised in Mouse using a purified recombinant fragment of KSHV ORF45 expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using KSHV ORF45 antibody (10R-1940)

Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced BCBL-1 cells (B) using KSHV ORF45 antibody with AEC staining.

Specifications

Host Mouse
Clone 2D4A5
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, ICC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN

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Images

  • Immunohistochemical staining using KSHV ORF45 antibody (10R-1940) | Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced BCBL-1 cells (B) using KSHV ORF45 antibody with AEC staining.
  • Western Blot analysis using KSHV ORF45 antibody (10R-1940) | Western Blot showing KSHV ORF45 antibody used against KSHV ORF45 recombinant protein.

Availability: In stock

Price: $375.00
Size: 100 ul
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