LAL antibody (10R-1955)
Mouse monoclonal LAL antibody
|Synonyms||Monoclonal LAL antibody, Anti-LAL antibody, Lysosomal acid lipase antibody, LAL antibody, Lysosomal acid lipase antibody, Anti LAL antibody|
|Immunogen||LAL antibody was raised in Mouse using a purified recombinant fragment of LAL expressed in E. coli as the immunogen.|
Western Blot analysis using LAL antibody (10R-1955)
Western Blot showing LAL antibody used against LAL recombinant protein.
|Form & Buffer||Purified antibody supplied in PBS containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000,|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||LAL functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.|
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