Lamin A antibody (10R-8081)

Mouse monoclonal Lamin A antibody

Synonyms Monoclonal Lamin A antibody, anti-Lamin A antibody, LMNA antibody, HGPS antibody, EMD2 antibody, FPLD antibody, CDCD1 antibody, LDP1 antibody, LGMD1B antibody, IDC antibody, Lamin-A/C antibody, CDDC antibody, LMN1 antibody, CMD1A antibody, PRO1 antibody, Lamin A
Specificity Recognizes an epitope located between residues 598-611 of lamin A and therefore 133A2 reacts exclusively with lamin A
Cross Reactivity Bovine, Canine, Human, Mouse, Rat
Applications FC, IHC, IHC-F, IHC-P, WB
Immunogen Lamin A antibody was raised in Mouse using partially purified recombinant human lamin A as the immunogen.

Specifications

Host Mouse
Clone 133A2
Isotype IgG3
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations FC: 1:100-1:200, IHC: 1:100-1:200, WB: 1:100-1:1000

General Information

Biological Significance Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization. Lamin A is specifically cleaved by caspase-6 and therefore serves as a marker for caspase-6 activation. During apoptosis the 70 kDa lamin A is cleaved to a large and small fragment. The cleavage of lamins results in nuclear disregulation and cell death.

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Availability: In stock

Price: $389.00
Size: 100 ug
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