LCK antibody (10R-2019)
Mouse monoclonal LCK antibody
|Synonyms||Monoclonal LCK antibody, Anti-LCK antibody, YT16 antibody, Lymphocyte-Specific Protein Tyrosine Kinase antibody, YT16 antibody, pp58lck antibody, Anti LCK antibody, pp58lck antibody, Lymphocyte-Specific Protein Tyrosine Kinase antibody, p56lck antibody, LCK antibody, p56lck antibody|
|Immunogen||LCK antibody was raised in Mouse using a purified recombinant fragment of human Lck expressed in E. coli as the immunogen.|
Western Blot analysis using LCK antibody (10R-2019)
Western Blot showing LCK antibody used against MOLT-4 (1), CCRF-CEM (2), CCRF-HSB-2 (3) and Jurkat (4) cell lysate.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.|
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