LDLRAP1 protein (His tag) (80R-2138)

Recombinant human LDLRAP1 protein (His tag)

Synonyms ARH1 protein, LDLRAP1, LDLRAP-1 protein, LDLRAP 1 protein, ARH protein, Low density lipoprotein receptor adaptor protein 1 protein, FHCB2 protein, LDLRAP-1, ARH2 protein, LDLRAP 1, FHCB1 protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of LDLRAP1 protein (His tag) (80R-2138)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-308 amino acids: MGSSHHHHHH SSGLVPRGSH MDALKSAGRA LIRSPSLAKQ SWGGGGRHRK LPENWTDTRE TLLEGMLFSL KYLGMTLVEQ PKGEELSAAA IKRIVATAKA SGKKLQKVTL KVSPRGIILT DNLTNQLIEN VSIYRISYCT ADKMHDKVFA YIAQSQHNQS LECHAFLCTK RKMAQAVTLT VAQAFKVAFE FWQVSKEEKE KRDKASQEGG DVLGARQDCT PPLKSLVATG NLLDLEETAK APLSTVSANT TNMDEVPRPQ ALSGSSVVWE LDDGLDEAFS RLAQSRTNPQ VLDTGLTAQD MHYAQCLSPV DWDKPDSSGT EQDDLFSF
Expression System E.coli
Purity > 90% pure
Molecular Weight 36.1 kDa (328aa), confirmed by MALDI-TOF
Tag/Conjugate His tag
Form & Buffer Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200mM NaCl
Concentration 0.5 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance LDLRAP1 (Low density lipoprotein receptor adapter protein 1) is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. LDLRAP1 is a cytosolic adaptor that couples LDLR to endocytic machinery. Defects in LDLRAP1 are the cause of autosomal recessive hypercholesterolemia (ARH). ARH is a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. Recombinant human LDLRAP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References
Add a Paper

J. Kosackaa, M. Gerickea, M. Nowickia, J. Kaczab, J. Borlakc, K. Spanel-Borowski

Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures

Neuroscience

Volume: 162 Issue: 2 Page: 282-291 DOI: 10.1016/j.neuroscience.2009.04.073

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Images

  • Coomassie Blue stained SDS-PAGE of LDLRAP1 protein (His tag) (80R-2138) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $365.00
Size: 100 ug
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