Livin protein (His tag) (80R-1056)
Purified recombinant Human Livin protein
|Synonyms||MLIAP protein, RNF50 protein, BIRC 7 protein, RNF50 protein, KIAP protein, Livin inhibitor of apoptosis isoform alpha protein, ML-IAP protein, RING finger protein 50 protein, Baculoviral IAP repeat-containing 7 protein, KIAP protein, Livin protein, Livin inhibitor of apoptosis isoform alpha Baculoviral IAP repeat containing 7 protein, ML IAP., MLIAP protein, Livin inhibitor of apotosis protein, Baculoviral IAP repeat containing protein 7 protein, RNF 50 protein, BIRC7 protein, Kidney inhibitor of apoptosis protein protein, Melanoma inhibitor of apoptosis protein protein|
Coomassie Blue stained SDS-PAGE of Livin protein (His tag) (80R-1056)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-298 amino acids: MGSSHHHHHH SSGLVPRGSH MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS|
|Purity||> 90% pure|
|Molecular Weight||34 kDa (318 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 1mM DTT, 0.1M NaCl, 2mM EDTA, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Livin is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING zinc finger (RZF) domain. Livin has direct interaction with several caspases including caspase-3, -7, and –9. This protein inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. Recombinant human Livin fused to His-tag at N-terminus was expressed in E. coli and purified by conventional chromatography techniques.|
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