Lyn antibody (10R-8541)

Mouse monoclonal Lyn antibody

Synonyms Monoclonal Lyn antibody, Anti-Lyn antibody, LYN antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antibody, BOS_13851 antibody, CH73-38P6.3 antibody, EGK_18962 antibody, Hck-2 antibody, JTK8 antibody, lck/Yes-related novel protein tyrosine kinase antibody, lyn-A antibody, lyn protein non-receptor kinase antibody, lyn protein tyrosine kinase antibody, p53Lyn antibody, p56Lyn antibody, RCJMB04_13j17 antibody, RP23-49A12.2 antibody, Tyrosine-protein kinase Lyn antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein antibody, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog antibody
Cross Reactivity Human, Mouse, Rat
Applications IP, WB
Immunogen Lyn antibody was raised in Mouse using a synthetic target peptide as the immunogen

Images

Western Blot analysis using Lyn antibody (10R-8541)

Specifications

Host Mouse
Clone 11A7
Isotype IgG2a kappa
Method of Purification Lyn antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The intracellular protein kinase Lyn participates both positively and negatively in B cell, mast cell, platelet and myeloid cell signaling. Lyn is the predominantly expressed Src-family kinase in B cells and its positive role is done through phosphorylation of the Igalpha and Igbeta subunits of B cell receptor. Genetic deletion of Lyn results in autoimmunity, renal disease and premature mortality in mice, and generation of hyperactive Lyn results in the same phenotype, revealing the importance of the balance of Lyn signaling.

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Images

  • Western Blot analysis using Lyn antibody (10R-8541) |

Availability: In stock

Price: $295.00
Size: 100 ul
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