MAG antibody (70R-14288)

Affinity purified Rabbit polyclonal MAG antibody

Synonyms Polyclonal MAG antibody, Anti-MAG antibody, SIGLEC4A antibody, Myelin associated glycoprotein antibody
Applications IHC-P, WB
Immunogen MAG antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human MAG, identical to the related rat and Rabbit sequences, as the immunogen

Images

Western blot analysis using MAG antibody (70R-14288)

Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Brain Tissue Lysate, Lane 3: Mouse Brain Tissue Lysate, Lane 4: Mouse Brain Tissue Lysate

Specifications

Host Rabbit
Isotype IgG
Method of Purification MAG antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance MAG is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is thought to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG.

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Images

  • Western blot analysis using MAG antibody (70R-14288) | Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Brain Tissue Lysate, Lane 3: Mouse Brain Tissue Lysate, Lane 4: Mouse Brain Tissue Lysate

Availability: In stock

Price: $270.00
Size: 100 ug
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