MAP2K1/2 antibody (Ser218,222) (70R-15009)
Rabbit polyclonal MAP2K1/2 antibody (Ser218,222)
|Synonyms||Polyclonal MAP2K1/2 antibody, Anti-MAP2K1/2 antibody, MAP2K 1/2 antibody, MAP2K-1/2 antibody, MAP2K1/2, Mitogen-Activated Protein Kinase 1 antibody, MAPKK1 antibody, MEK1 antibody, MKK1 antibody, PRKMK1 antibody, Mitogen-Activated Protein Kinase 2 antibody, MAPKK2 antibody, MEK2 antibody, MKK2 antibody, PRKMK2 antibody|
Western Blot analysis using MAP2K1/2 antibody (Ser218,222) (70R-15009)
Western Blot of NIH 3T3 cell lysates showing specific immunolabeling of ~45k MEK 1/2 protein phosphorylated at Ser218 and Ser222.
|Method of Purification||MAP2K1/2 antibody was purified by affinity chromatography|
|Form & Buffer||Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol|
Usage & Assay Information
|Usage Recommendations||WB: 1:1000|
|Biological Significance||MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.|
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