MAP2K1 antibody (Thr386) (70R-15011)

Rabbit polyclonal MAP2K1 antibody (Thr386)

Synonyms Polyclonal MAP2K1 antibody, Anti-MAP2K1 antibody, MAP2K 1 antibody, MAP2K-1 antibody, MAP2K1, Mitogen-activated protein kinase kinase 1 antibody, MEK1 antibody, PRKMK1 antibody, ERK activator kinase 1 antibody, MAP kinase kinase 1 antibody
Applications WB

Images

Western Blot analysis using MAP2K1 antibody (Thr386) (70R-15011)

Western blot of human T47D cells showing specific immunolabeling of ~45k MEK 1 (Control)

Specifications

Host Rabbit
Method of Purification MAP2K1 antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000

General Information

Biological Significance Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Images

  • Western Blot analysis using MAP2K1 antibody (Thr386) (70R-15011) | Western blot of human T47D cells showing specific immunolabeling of ~45k MEK 1 (Control)

Availability: In stock

Price: $335.00
Size: 100 ul
OR
Shipping
View Our Distributors