MAP2K2 antibody (10R-1822)

Mouse monoclonal MAP2K2 antibody

Synonyms Monoclonal MAP2K2 antibody, Anti-MAP2K2 antibody, Mitogen-Activated Protein Kinase 2 antibody, MAPKK2 antibody, MEK2 antibody, MKK2 antibody, PRKMK2 antibody, MAP2K2, MAPK 2, MAPK-2, MAPK 2 antibody, MAPK-2 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, FC, IF, WB
Immunogen MAP2K2 antibody was raised in Mouse using a purified recombinant fragment of human MAP2K2 expressed in E. coli as the immunogen.

Images

Flow Cytometric assay using Western Blot analysis using MAP2K2 antibody (10R-1822) (MAP2K2 antibody)

FC analysis of Hela cells using anti-MAP2K2 antibody (green) and negative control (purple).

Specifications

Host Mouse
Clone 7F5
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, FC: 1:200-1:400, IF: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.

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Images

  • Flow Cytometric assay using Western Blot analysis using MAP2K2 antibody (10R-1822) (MAP2K2 antibody) | FC analysis of Hela cells using anti-MAP2K2 antibody (green) and negative control (purple).
  • Western Blot analysis using MAP2K2 antibody (10R-1822) | Western Blot showing MAP2K2 antibody used against PC-12 (1), Jurkat (2), Hela (3) and NIH/3T3 (4) cell lysate.
  • Immunofluorescent staining using Western Blot analysis using MAP2K2 antibody (10R-1822) (MAP2K2 antibody) | Immunofluorescence analysis of Hela cells using anti-MAP2K2 antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Availability: In stock

Price: $345.00
Size: 100 ul
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