MAP2K4 antibody (10R-2097)
Mouse monoclonal MAP2K4 antibody
|Synonyms||Monoclonal MAP2K4 antibody, Anti-MAP2K4 antibody, Mitogen-activated protein kinase kinase 4 antibody, MAPK4-2 antibody, MAPK4 2 antibody, MAPK4 2, SAPK/ERK kinase 1 antibody, MAPK/ERK kinase 4 antibody, MAPKK 4 antibody, MAPK4-2, MAP2K4|
|Immunogen||MAP2K4 antibody was raised in Mouse using a purified recombinant fragment of MAP2K4 expressed in E. coli as the immunogen.|
Immunohistochemical staining using MAP2K4 antibody (10R-2097)
Immunohistochemical analysis of paraffin-embedded human thymoma tissue (left) and spleen tissue (right), showing cytoplasmic localization using MAP2K4 antibody with DAB staining.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, IHC: 1:200-1:1000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MAP2K4 is a a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is adirect activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shownto activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.|
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