MAPK1 protein (His tag) (80R-1232)
Purified recombinant Human MAPK1 protein
|Synonyms||ERK protein, p41 protein, PRKM1 protein, MAPK 1, p41mapk protein, MAPK 2 protein, MAPK-1, MAPK2 protein, MAPK 1., ERK 2 protein, ERK2 protein, MAPK-1 protein, Extracellular Signal Regulated Kinase 2 protein, ERT1 protein, P42MAPK protein, p38 protein, p40 protein, MAPK1, Mitogen-activated protein kinase 1 MAP kinase 2 protein, PRKM2 protein, MAPK 1 protein|
Coomassie Blue stained SDS-PAGE of MAPK1 protein (His tag) (80R-1232)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-360 amino acids: MGSSHHHHHH SSGLVPRGSH MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS|
|Purity||> 95% pure|
|Molecular Weight||43.5 kDa (380aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT and 0.1 M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MAPK1, also known as ERK (extracellular signal-regulated kinase), acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Recombinant human MAPK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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