MAPK14 antibody (70R-10491)

Affinity purified rabbit polyclonal MAPK14 antibody

Synonyms Polyclonal MAPK14 antibody, Anti-MAPK14 antibody, MAPK14, MAPK 14, mitogen-activated protein kinase 14 antibody, MAPK-14, MAPK-14 antibody, MAPK 14 antibody
Cross Reactivity Human, Mouse, Rat, Dog, Bovine, African Clawed Frog
Applications IHC, WB
Immunogen MAPK14 antibody was raised in rabbit using the C terminal of MAPK14 as the immunogen

Images

Immunohistochemical staining using MAPK14 antibody (70R-10491)

MAPK14 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Hepatocytes (arrows) in Human Liver. Magnification is at 400X.

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance MAPK14 encodes a protein which is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

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Images

  • Immunohistochemical staining using MAPK14 antibody (70R-10491) | MAPK14 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Hepatocytes (arrows) in Human Liver. Magnification is at 400X.
  • Western Blot analysis using MAPK14 antibody (70R-10491) | MAPK14 antibody (70R-10491) used at 0.2-1 ug/ml to detect target protein.

Availability: In stock

Price: $345.00
Size: 50 ug
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