MAPK14 protein (His tag) (80R-2042)
Recombinant human MAPK14 protein (His tag)
|Synonyms||RK protein, MAPK-14 protein, MAPK 14, Mxi2 protein, MAPK-14, CSBP2 protein, MAPK14, p38 protein, PRKM15 protein, CSBP1 protein, EXIP protein, CSPB1 protein, SAPK2A protein, p38ALPHA protein, CSBP protein, MAPK 14 protein, Mitogen-activated protein kinase 14 protein, PRKM14 protein|
SDS-PAGE analysis of MAPK14 protein (His tag) (80R-2042)
SDS-PAGE gel analysis of MAPK14 protein (His tag) where the figure is annotated with amount of protein run on the gel.
|Residues||1-360 amino acids: MGSSHHHHHH SSGLVPRGSH MGSMSQERPT FYRQELNKTI WEVPERYQNL SPVGSGAYGS VCAAFDTKTG LRVAVKKLSR PFQSIIHAKR TYRELRLLKH MKHENVIGLL DVFTPARSLE EFNDVYLVTH LMGADLNNIV KCQKLTDDHV QFLIYQILRG LKYIHSADII HRDLKPSNLA VNEDCELKIL DFGLARHTDD EMTGYVATRW YRAPEIMLNW MHYNQTVDIW SVGCIMAELL TGRTLFPGTD HIDQLKLILR LVGTPGAELL KKISSESARN YIQSLTQMPK MNFANVFIGA NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE PVADPYDQSF ESRDLLIDEW KSLTYDEVIS FVPPPLDQEE MES|
|Purity||> 90% pure|
|Molecular Weight||43.7 kDa (383aa), confirmed by MALDI-TOF|
|Form & Buffer||Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 100mM NaCl|
Usage & Assay Information
|Usage Recommendations||MAPK14 protein (His tag) has been used in SDS-PAGE, and may be suitable for use in other applications, to be determined by the end user.|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||MAPK14 (Mitogen-activated protein kinase 14) is a member of the MAP kinase family. MAPK14 is most closely related to p38 MAP kinases(MAPKs). MAPKs are activated primarily in response to inflammatory cytokines and cellular stress, and inhibitors which target the MAPK14 and MAPK11 have shown potential for the treatment of inflammatory disease. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response. Recombinant human MAPK14 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
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