MCM6 antibody (70R-14306)

Affinity purified Rabbit polyclonal MCM6 antibody

Synonyms Polyclonal MCM6 antibody, Anti-MCM6 antibody, MCM 6 antibody, Minichromosome Maintenance Complex Component 6 antibody, MCM-6 antibody, MCM-6, MCM6, MCM 6
Applications ICC, IHC-P, WB
Immunogen MCM6 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human MCM6, different from the related rat sequence by one amino acid and from the related Rabbit sequence by two amino acids as the immunogen

Images

Western blot analysis using MCM6 antibody (70R-14306)

Lane 1: U87 Cell Lysate, Lane 2: COLO320 Cell Lysate, Lane 3: HELA Cell Lysate, Lane 4: MCF-7 Cell Lysate, Lane 5: JURKAT Cell Lysate

Specifications

Host Rabbit
Isotype IgG
Method of Purification MCM6 antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

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Images

  • Western blot analysis using MCM6 antibody (70R-14306) | Lane 1: U87 Cell Lysate, Lane 2: COLO320 Cell Lysate, Lane 3: HELA Cell Lysate, Lane 4: MCF-7 Cell Lysate, Lane 5: JURKAT Cell Lysate
  • Immunohistochemical staining using MCM6 antibody (70R-14306) | Immunohistochemistry of paraffin embedded section of Rat Brain Tissue
  • Immunohistochemical staining using MCM6 antibody (70R-14306) | Immunohistochemistry of paraffin embedded section of Human Intestinal Cancer Tissue
  • Immunocytochemistry staining using MCM6 antibody (70R-14306) | Immunocytochemistry staining of MCM6 in HeLa cells

Availability: In stock

Price: $270.00
Size: 100 ug
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