MDS1 protein (His tag) (80R-3559)
Purified recombinant MDS1 protein (His tag)
|Synonyms||Myelodysplasia syndrome 1 protein, MDS1-EVI1 protein, PRDM3 protein, MDS 1 protein, MDS-1 protein|
Coomassie blue stained SDS-PAGE of MDS1 protein (His tag) (80R-3559)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-169 aa: MGSSHHHHHH SSGLVPRGSH MGSMRSKGRA RKLATNNECV YGNYPEIPLE EMPDADGVAS TPSLNIQEPC SPATSSEAFT PKEGSPYKAP IYIPDDIPIP AEFELRESNM PGAGLGIWTK RKIEVGEKFG PYVGEQRSNL KDPSYGWEVH LPRSRRVSVH SWLYLGKRSS DVGIAFSQAD VYMPGLQCAF LS|
|Purity||> 85% pure|
|Method of Purification||MDS1 protein was purified by using conventional chromatography techniques|
|Molecular Weight||21.1 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||MDS1 is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.|
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