MIP1 beta protein (30R-AM017)

Purified recombinant Human MIP1 beta protein

Synonyms MIP beta-1 protein, MIP beta 1, MIP beta-1, ACT-2 protein, CCL4 protein, Macrophage Inflammatory Protein-1 beta protein, MIP-1 beta protein, MIP1 beta, MIP beta 1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of MIP1 beta protein corresponding to amino acids APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN.
Expression System E.coli
Purity > 98% pure
Molecular Weight 7.8 kDa
Form & Buffer Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and Mouse MIP-1 alpha and MIP-1 beta are active on human and Mouse hematopoietic cells.

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Availability: In stock

Price: $225.00
Size: 10 ug
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