MIS12 protein (His tag) (80R-2632)
Purified recombinant Human MIS12 protein (His tag)
|Synonyms||MTW 1 protein, MIS-12, MIS 12 protein, MIS12, KNTC2AP protein, MTW1 protein, MTW-1 protein, Protein MIS12 homolog protein, hMis12 protein, MIS-12 protein, MIS 12|
SDS-PAGE analysis of MIS12 protein (His tag) (80R-2632)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-205 aa: MGSSHHHHHH SSGLVPRGSH MGSMSVDPMT YEAQFFGFTP QTCMLRIYIA FQDYLFEVMQ AVEQVILKKL DGIPDCDISP VQIRKCTEKF LCFMKGHFDN LFSKMEQLFL QLILRIPSNI LLPEDKCKET PYSEEDFQHL QKEIEQLQEK YKTELCTKQA LLAELEEQKI VQAKLKQTLT FFDELHNVGR DHGTSDFRES LVSLVQNSRK LQNIRDNVEK ESKRLKIS|
|Method of Purification||MIS12 protein was purified using Protein G affinity chromatography|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 10% glycerol|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Protein MIS12 homolog, also known as MIS12, is a component of the MIS12 complex, which is required for kinetochore formation during mitosis and normal chromosome alignment and segregation. The MIS12 complex consists of MIS12, DSN1, NSL1 and PMF-1. MIS12 is part of a network of complexes that provide microtubule attachment and generates pulling forces from depolymerization. Recombinant human MIS12 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
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