MLF1IP protein (His tag) (80R-3628)
Purified recombinant MLF1IP protein (His tag)
|Synonyms||CENP50 protein, CENPU protein, CENPU50 protein, KLIP1 protein, PBIP1 protein, MLF 1IP protein, MLF-1IP protein|
Coomassie blue stained SDS-PAGE of MLF1IP protein (His tag) (80R-3628)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||147-418a MGSSHHHHHH SSGLVPRGSH MGSTRRKVKS AEKISTQRHE VIRTTASSEL SEKPAESVTS KKTGPLSAQP SVEKENLAIE SQSKTQKKGK ISHDKRKKSR SKAIGSDTSD IVHIWCPEGM KTSDIKELNI VLPEFEKTHL EHQQRIESKV CKAAIATFYV NVKEQFIKML KESQMLTNLK RKNAKMISDI EKKRQRMIEV QDELLRLEPQ LKQLQTKYDE LKERKSSLRN AAYFLSNLKQ LYQDYSDVQA QEPNVKETYD SSSLPALLFK ARTLLGAESH LRNINHQLEK LLDQG|
|Purity||> 80% pure|
|Method of Purification||MLF1IP protein was purified by using conventional chromatography techniques|
|Molecular Weight||33.7 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol0.4M Urea|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||MLF1IP, as known as centromere, is a specialized chromatin domain, present throughout the cell cycle that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. It plays an important role in the correct PLK1 localization to the mitotic kinetochores. It is a scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. It also involved in transcriptional repression.|
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